基于PubMed数据库毛孢子菌病临床研究文献计量学分析

目的分析国际毛孢子菌病文献概貌，了解毛孢子菌病临床相关研究现状，为更好地开展毛孢子菌临床研究提供思路和依据。方法利用汤森路透TDA软件分析PubMed数据库收录的毛孢子菌病临床相关文献的时间、国家、期刊、作者和高频主题词分布，并获得作者合作网络图。结果临床毛孢子菌病相关文献始于1970年，经过1981～1992年的快速增长期后，近年来数量增长不明显。日本在临床毛孢子菌病研究领域具有领先优势，美国、印度、巴西、法国和中国内地发文量也较多。刊载毛孢子菌病临床研究文献最多的期刊是《日本胸部疾病杂志》（Nihon Kyobu Shikkan Gakkai Zasshi，Japa—nese Journal of Thoracic Diseases）和《临床微生物学杂志》（Journal of Clinical Microbiology）。发文量最多的作者分别是熊本大学医学部的Ando M、Araki S和琦玉医科大学的Sakata T。毛孢子菌病的高频主题词涉及毛孢子菌病的诊治、宿主免疫和毛孢子菌致病机制等。结论日本和美国仍是相关领域的研究大国，但近5a来，更多的中国科研团队加入到这一研究领域，提高了我国学者的学术影响力。侵袭性毛孢子菌病的诊治是临床毛孢子菌病研究的主要关注点。

A bibliometric analysis on clinical research of trichosporonosis from PubMed database

Objective To give an outline of the development of clinical research on trichosporonosis worldwide by an over- view of related literature from PubMed for providing ideas and basis for further research. Methods Medical literature on clin- ical trichosporonosis in PubMed database was analyzed by using a bibliometric tool, Thomson Data Analyzer. The distribu- tions of years, nations, journals, and currently hot topics on trichosporonosis were analyzed. Results The literature of tri- chosporonosis was traced back to1970, went through the period of rapid growth from 1981 to 1992, the numbers of paper published every year was stable recent years. Japan has leading advantages in the field of trichosporonosis. The numbers of papers from United States, India, Brazil, France and China were on the top, while Ando M and Araki S from Kumamoto U- niversity Medical School and Sakata T from Saitama Medical School were the top three authors in these publications. The journals published the most papers of trichosporonosis were Japanese Journal of Thoracic Diseases and Journal of Clinical Mi- crobiology. Hot topics in the field of trichosporonosis were related to diagnosis, treatment, status of host immune and patho- genesis of Trichosporon spp. Conclusion Japan and United States are the top two countries in this field. More Chinese re- search teams join to this field of trichosporonosis research in recent five years. Diagnosis and treatment are the hot topics in this field.