Sequence complementarity-driven nonenzymatic ligation of RNA |
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| Authors: | Pino Samanta Costanzo Giovanna Giorgi Alessandra Di Mauro Ernesto |
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| Affiliation: | Dipartimento di Biologia e Biotecnologie Charles Darwin, Sapienza Universita? di Roma, P.le Aldo Moro, 5, Rome 00185, Italy. |
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| Abstract: | We report two reactions of RNA G:C sequences occurring nonenzymatically in water in the absence of any added cofactor or metal ion: (a) sequence complementarity-driven terminal ligation and (b) complementary sequence adaptor-driven multiple tandemization. The two abiotic reactions increase the chemical complexity of the resulting pool of RNA molecules and change the Shannon information of the initial population of sequences. |
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