Protein kinases of the human malaria parasite Plasmodium falciparum: the kinome of a divergent eukaryote |
| |
| Authors: | Pauline Ward Leila Equinet Jeremy Packer Christian Doerig |
| |
| Institution: | (1) Wellcome Centre for Molecular Parasitology, University of Glasgow, 56 Dumbarton Road, Glasgow, G11 6NU, Scotland, UK;(2) INSERM U609, Wellcome Centre for Molecular Parasitology, University of Glasgow, 56 Dumbarton Road, Glasgow, G11 6NU, Scotland, UK;(3) Division of Advanced Technologies, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, 60064, IL, USA |
| |
| Abstract: | Background Malaria, caused by the parasitic protist Plasmodium falciparum, represents a major public health problem in the developing world. The P. falciparumgenome has been sequenced, which provides new opportunities for the identification of novel drug targets. Eukaryotic protein
kinases (ePKs) form a large family of enzymes with crucial roles in most cellular processes; hence malarial ePKS represent
potential drug targets. We report an exhaustive analysis of the P. falciparumgenomic database (PlasmoDB) aimed at identifying and classifying all ePKs in this organism. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
