Involvement of the AT1 receptor in the venoconstriction induced by angiotensin II in both the inferior vena cava and femoral vein |
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Authors: | da Silva Osmar Gomes Rossignoli Patrícia de Souza Carrillo-Sepúlveda Maria Alícia Barreto-Chaves Maria Luiza Morais Chies Agnaldo Bruno |
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Institution: | a Faculty of Pharmacy and Biochemistry, University of Marilia, SP, Brazil b Laboratory of Pharmacology, Faculty of Medicine of Marília, Av. Monte Carmelo, 800, Fragata, 17 519-030 Marília, SP, Brazil c Department of Pharmacology, Biosciences Institute of Botucatu, SP, Brazil d Laboratory of Cell Biology and Functional Anatomy, Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil |
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Abstract: | Although angiotensin II-induced venoconstriction has been demonstrated in the rat vena cava and femoral vein, the angiotensin II receptor subtypes (AT1 or AT2) that mediate this phenomenon have not been precisely characterized. Therefore, the present study aimed to characterize the pharmacological receptors involved in the angiotensin II-induced constriction of rat venae cavae and femoral veins, as well as the opposing effects exerted by locally produced prostanoids and NO upon induction of these vasomotor responses. The obtained results suggest that both AT1 and AT2 angiotensin II receptors are expressed in both veins. Angiotensin II concentration-response curves were shifted toward the right by losartan but not by PD 123319 in both the vena cava and femoral vein. Moreover, it was observed that both 10−5 M indomethacin and 10−4 M L-NAME improve the angiotensin II responses in the vena cava and femoral vein. In conclusion, in the rat vena cava and femoral vein, angiotensin II stimulates AT1 but not AT2 to induce venoconstriction, which is blunted by vasodilator prostanoids and NO. |
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Keywords: | Angiotensin II Femoral vein Nitric Oxide Prostanoids Receptor Vena cava |
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