Replication intermediates as substrates for DNA rearrangements |
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| Authors: | R B Painter L N Kapp |
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| Affiliation: | Laboratory of Radiobiology and Environmental Health, University of California, San Francisco 94143-0750. |
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| Abstract: | A model for the formation of DNA rearrangements in somatic cells is presented. Two double-strand breaks at the junctions between unreplicated DNA and newly replicated DNA generate four double-stranded DNA molecules that can recombine to form tandem duplications, inversions, deletions and extrachromosomal DNA circles. |
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