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Solid-phase synthesis of di- and tripeptidic hydroxamic acids as inhibitors of procollagen C-proteinase
Authors:Dankwardt S M  Billedeau R J  Lawley L K  Abbot S C  Martin R L  Chan C S  Van Wart H E  Walker K A
Affiliation:Roche Bioscience, Inflammatory Diseases Unit, Palo Alto, CA 94304, USA. sharon.dankwardt@roche.com
Abstract:A solid-phase approach to the rapid synthesis of di- and tripeptide-like hydroxamic acids is presented. These compounds are shown to be potent inhibitors of procollagen C-proteinase (PCP).
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