Solid-phase synthesis of di- and tripeptidic hydroxamic acids as inhibitors of procollagen C-proteinase |
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Authors: | Dankwardt S M Billedeau R J Lawley L K Abbot S C Martin R L Chan C S Van Wart H E Walker K A |
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Affiliation: | Roche Bioscience, Inflammatory Diseases Unit, Palo Alto, CA 94304, USA. sharon.dankwardt@roche.com |
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Abstract: | A solid-phase approach to the rapid synthesis of di- and tripeptide-like hydroxamic acids is presented. These compounds are shown to be potent inhibitors of procollagen C-proteinase (PCP). |
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