细胞电融合技术及最新进展

细胞电融合（cell electrofusion）是一种发展迅速的细胞工程技术，在细胞融合研究领域得到了最广泛的应用。细胞电融合利用细胞在相对电极之间的介电电泳，诱导细胞按特定方向排列，通过电极间产生的较高场强的电脉冲使相互接触的细胞发生电穿孔，进而发生电融合。融合后的细胞得到了不同细胞的遗传物质，具有新的遗传或生物特性。目前，细胞电融合技术对生物医学、农业等相关领域的研究具有非常重要的意义。本文介绍了细胞电融合技术及其最新研究动态，并简单介绍了本实验室在该领域的研究进展。

Advance in Cell Electrofusion Technology

As one of the most widely used technology in cell fusion, cell electrofusion is a rapidly developing cell engineering method, which utilizes dielectrophoretic force to induce cell alignment. Aligned cells are electroporated and subsequently electrofused within high electric field strength. These fused cells obtain different genetic materials from individual parent cells, which can show new genetic characteristics. At present, cell electrofusion is of important significance in biomedical and agricultural research. In the paper, the theoretical fundamental of electrofusion and up-to-date development are reviewed. Some relative research in our laboratory is also described.