Design, synthesis and biological activity of novel C2-C3' N-Linked macrocyclic taxoids |
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Authors: | Ojima Iwao Geng Xudong Lin Songnian Pera Paula Bernacki Ralph J |
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Institution: | Department of Chemistry, State University of New York at Stony Brook, NY 11794-3400, USA. iojima@notes.cc.sunysb.edu |
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Abstract: | A series of novel macrocyclic taxoids was designed and synthesized by connecting the C-2 and C-3' N positions of the taxoid framework with various tethers. Cytotoxicity of these macrocyclic taxoids was evaluated against a human breast cancer cell line LCC6-WT, and a couple of the taxoids exhibited 0.09-0.3 microM IC(50) values. |
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