Agonist-induced down-regulation of α_(1B)-adrenergic receptor in HEK293 cells transfected with α_(1B)cDNA |
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引用本文: | 许开明,韩启德,田斌,张幼怡.Agonist-induced down-regulation of α_(1B)-adrenergic receptor in HEK293 cells transfected with α_(1B)cDNA[J].中国科学:生命科学英文版,1998(3). |
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作者姓名: | 许开明 韩启德 田斌 张幼怡 |
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作者单位: | Institute of Vascular Medicine,Third Hospital,Beijing Medical University,Beijing 100083,China |
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基金项目: | ProjectsupportedbytheNationalNaturalScienceFoundationofChina(GrantNo .394 70 2 6 8)andtheChinaMedicineBoardofNewYorkInc . |
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摘 要: | α1adrenergicreceptors(α1AR)belongtothesuperfamilyofGproteincoupledreceptors.Prolongedactivationofthesereceptorswouldleadtoadecreaseinagonistsensitivity.Theprocessmayberelatedtoreceptordownregulation,sequestrationandphospholation,etc.Desensitizationofα1BAR…
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关 键 词: | α 1B- adrenergic receptor desensitization down regulation gene expression. |
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