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Agonist-induced down-regulation of α_(1B)-adrenergic receptor in HEK293 cells transfected with α_(1B)cDNA
引用本文:许开明,韩启德,田斌,张幼怡.Agonist-induced down-regulation of α_(1B)-adrenergic receptor in HEK293 cells transfected with α_(1B)cDNA[J].中国科学:生命科学英文版,1998(3).
作者姓名:许开明  韩启德  田斌  张幼怡
作者单位:Institute of Vascular Medicine,Third Hospital,Beijing Medical University,Beijing 100083,China
基金项目:ProjectsupportedbytheNationalNaturalScienceFoundationofChina(GrantNo .394 70 2 6 8)andtheChinaMedicineBoardofNewYorkInc .
摘    要:α1adrenergicreceptors(α1AR)belongtothesuperfamilyofGproteincoupledreceptors.Prolongedactivationofthesereceptorswouldleadtoadecreaseinagonistsensitivity.Theprocessmayberelatedtoreceptordownregulation,sequestrationandphospholation,etc.Desensitizationofα1BAR…

关 键 词:α  1B-  adrenergic  receptor    desensitization    down  regulation    gene  expression.
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