The role of arachidonate lipoxygenase in the release of SRS-A from guinea-pig chopped lung |
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| Authors: | HR Morris PJ Piper GW Taylor JR Tippins |
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| Institution: | 1. Department of Biochemistry, Imperial College of Science and Technology, South Kensington, London S.W.7 UK;2. Department of Pharmacology, Institute of Basic Medical Sciences, Royal College of Surgeons of England, Lincoln''s Inn Fields, London WC2A 3PN UK |
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| Abstract: | The immunological release of SRS-A was investigated in guinea-pig chopped lung. A number of unsaturated fatty acids, all of which are substrates for arachidonate lipoxygenase were found to potentiate the release of SRS-A. This potentiation was enhanced by indomethacin, a cyclo-oxygenase inhibitor, and completely reversed by nordihydroguaiaretic acid (NDGA) and eicosatetraynoic acid (ETA) which inhibit lipoxygenase. This suggests that some aspect of arachidonate lipoxygenase action stimulates release of SRS-A and that release of SRS-A is increased by redirection of arachidonic acid (AA) metabolism via the lipoxygenase pathway (Hamberg, 1976). However, although exogenous 14C-AA increased SRS-A output it was not incorporated into SRS-A. |
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