Manganese accumulates in iron-deficient rat brain regions in a heterogeneous fashion and is associated with neurochemical alterations |
| |
Authors: | Erikson Keith M Shihabi Zakariya K Aschner Judy L Aschner Michael |
| |
Institution: | (1) Department of Physiology and Pharmacology, Wake Forest University School of Medicine, 27157-1083 Winston-Salem, NC;(2) Department Pathology, Wake Forest University School of Medicine, 27157-1083 Winston-Salem, NC;(3) Department Pediatrics, Wake Forest University School of Medicine, 27157-1083 Winston-Salem, NC |
| |
Abstract: | Previous studies have shown that iron deficiency (ID) increases brain manganese (Mn), but specific regional changes have not
been addressed. Weanling rats were fed one of three semipurified diets: control (CN), iron deficient (ID), or iron deficient/manganese
fortified (IDMn+). Seven brain regions were analyzed for Mn concentration and amino acid (glutamate, glutamine, taurine, γ-aminobutyric
acid) concentrations. Both ID and IDMn+ diets caused significant (p<0.05) increases in Mn concentration across brain regions compared to CN. The hippocampus was the only brain region in which
the IDMn+ group accumulated significantly more Mn than both the CN and ID groups. ID significantly decreased GABA concentration
in hippocampus, caudate putamen, and globus pallidus compared to CN rats. Taurine was significantly increased in the substantia
nigra of the IDMn+ group compared to both ID and CN. ID also altered glutamate and glutamine concentrations in cortex, caudate
putamen, and thalamus compared to CN. In the substantia nigra, Mn concentration positively correlated with increased taurine
concentration, whereas in caudate putamen, Mn concentration negatively correlated with decreased GABA. These data show that
ID is a significant risk factor for central nervous system Mn accumulation and that some of the neurochemical alterations
associated with ID are specifically attributable to Mn accumulation. |
| |
Keywords: | Rat brain iron deficiency manganese GABA glutamate |
本文献已被 PubMed SpringerLink 等数据库收录! |
|