Photochemical study of the interaction of phenothiazine derivatives with spin labelled lecithin multibilayers. |
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| Authors: | F Leterrier R Kersanté |
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| Affiliation: | Division de Biophysique du Centre de Recherches du Service de Santé des Armées, 1 bis rue du Lieutenant Raoul Batany 92140-Clamart, France |
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| Abstract: | Nitroxide free radicals are destroyed by ultraviolet irradiation in the presence of phenothiazine derivatives. This property has been used in order to determine the type of interaction of these drugs with spin-labelled lecithin multibilayers. Kinetic measurements of the spin label signal decay under irradiation have shown that chlorpromazine and perphenazine are preferentially located in the polar part of the bilayer, whereas promethazine and oxidized derivatives of chlorpromazine are found principally in the hydrophobic part. |
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