Subcellular aging markers of retinal pigment epithelium in Japanese quail Coturnix japonica |
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| Authors: | N. B. Seryozhnikova P. P. Zak L. S. Pogodina N. N. Trofimova T. V. Lipina M. A. Ostrovsky |
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| Affiliation: | 1. Department of Biology, Moscow State University, Moscow, Russia
2. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia
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| Abstract: | Age-related changes of retinal pigment epithelium of the Japanese quail, which at present is a promising experimental model of accelerated aging, were studied by electron microscopy using morphometric analysis. It was established that, along with accumulation of lipofuscin granules and ultrastructural changes of the Bruch’s membrane, changes in the shape of nuclei and mitochondria (increase in the portion of ring-shaped and dumbbell-like mitochondria), decrease in the amount of myeloid bodies, and disorganization of basal infoldings are also aging markers of retinal pigment epithelium. |
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