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Concentration of toxins in endosomal compartment of the cells pretreated with ricin and viscumin |
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| Authors: | Sh. Yu. Khapchaev S. S. Gutor I. P. Kaminskii E. E. Kremer S. V. Krivoshchekov I. V. Mil’to A. G. Pershina I. V. Petrova I. V. Saltykova N. S. Subbotina K. V. Khvorilova |
| Affiliation: | 1. Department of Biology, Moscow State University, Moscow, 119991, Russia 2. Biomedical Department, Siberian State Medical University, Moskovskii trakt 2, Tomsk, 634050, Russia |
| Abstract: | Data on volume of the intracellular compartment where the internalized toxin is located and toxin concentration in this compartment have been obtained. Suggestions have been made about a role of toxin molecule aggregates in the translocation of A-chain into cytosol, which leads to cell death. |
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