A high-resolution genetic map of mouse Chromosome 15 encompassing the Dominant megacolon (Dom) locus |
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| Authors: | A Puliti M O Prehu D Simon-Chazottes L Ferkdadji M Peuchmaur M Goossens J L Guénet |
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| Institution: | (1) Unité INSERM U91, Hôpital Henri Mondor, 51, avenue du Maréchal de Lattre de Tassigny, 94010 Créteil Cedex, France;(2) Unité de Génétique des Mammifères, Institut Pasteur, Paris, France;(3) Service d'anatomie-pathologique, Hôpital Robert Debré, Paris, France |
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| Abstract: | Dominant megacolon (Dom) is one of four mutations in the mouse that can produce a phenotype similar to Hirschsprung disease in human. The Dom gene product is not known, and no candidate region has been defined for a possible human homolog. In this publication we report mapping the Dom locus with high definition, using several intra- and interspecific crosses and a set of 16 Chr 15-specific microsatellites flanking this locus. |
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