Effect of stress-induced lipid peroxidation on functions of rat peritoneal macrophages |
| |
Authors: | Izgüt-Uysal V Nimet Tan Ruken Bülbül Mehmet Derin Narin |
| |
Institution: | Akdeniz University, Faculty of Medicine, Department of Physiology, 07070 Antalya, Turkey. nimetu@akdeniz.edu.tr |
| |
Abstract: | The aim of the present study was to investigate the effects of stress-induced lipid peroxidation on macrophages' functions. Animals were subjected to 4 h immobilization at 4 degrees C in restraining devices. The peritoneal macrophages obtained from rats exposed to cold and restraint stress exhibited an increase in lipid peroxidation and a decline of chemotaxis and phagocytosis compared with control rats. After supplementation with vitamin E, the increment in thiobarbituric acid reactive substances (TBARS) content as the oxidative stress marker and the decline of chemotaxis and phagocytosis in peritoneal macrophages observed during cold-restraint stress was significantly removed. No significant change in catalase activity of peritoneal macrophages was observed in groups exposed to cold-restraint stress and treated with vitamin E. These findings indicate that phagocytic and chemotactic capacities of peritoneal macrophages are decreased by cold-restraint stress and this effect of stress may be related to lipid peroxidation. |
| |
Keywords: | Lipid peroxidation Phagocytosis Chemotaxis Catalase activity Vitamin E |
本文献已被 PubMed 等数据库收录! |