Photodynamic activity of anthraquinones isolated from Heterophyllaea pustulata Hook f. (Rubiaceae) on MCF-7c3 breast cancer cells |
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Authors: | L.R. Comini,I.M. Fernandez,N.B. Rumie VittarS.C. Nú ñ ez Montoya,J.L. Cabrera,V.A. Rivarola |
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Affiliation: | a Farmacognosia, Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba (IMBIV-CONICET), Ciudad Universitaria, CP 5000 Córdoba, Argentina b Departamento de Biología Molecular, Facultad de Ciencias Exactas Fisicoquímicas y Naturales, Universidad Nacional de Río Cuarto, CP 5800 Río Cuarto, Córdoba, Argentina |
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Abstract: | Searching for agents that could be effective in the treatment of cancer, special highlight has focused on the study of numerous plant-derived compounds. We previously demonstrated that anthraquinones (AQs) isolated from a vegetal species: Heterophyllaea pustulata Hook f. (Rubiaceae), such as rubiadin, rubiadin-1-methyl ether, soranjidiol, soranjidiol-1-methyl ether exhibit photosensitizing properties without antecedents as photodynamic agents in malignant cells. In the present study, we investigated the potential role of these AQs as a phototoxic agent against human breast carcinoma using MCF-7c3 cells. All AQs exhibited significant photocytotoxicity on cancer cells at the concentration of 100 μM with 1 J/cm2 light dose, resulting soranjidiol-1-methyl ether in complete cell destruction. The observed cellular killing by photoactivated AQs exhibited close relation with singlet oxygen production, except for soranjidiol-1-methyl ether, where cell viability decrease is in relation to uptake by tumor cells. |
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Keywords: | Cancer Photodynamic therapy Heterophyllaea pustulata Anthraquinones Photosensitizers |
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