PeakAnalyzer: Genome-wide annotation of chromatin binding and modification loci |
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Authors: | Mali Salmon-Divon Heidi Dvinge Kairi Tammoja Paul Bertone |
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Affiliation: | (1) EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, CB10 1SD, UK;(2) Department of Cell and Molecular Biology, Karolinska Institutet, S-171 77 Stockholm, Sweden |
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Abstract: | Background Functional genomic studies involving high-throughput sequencing and tiling array applications, such as ChIP-seq and ChIP-chip, generate large numbers of experimentally-derived signal peaks across the genome under study. In analyzing these loci to determine their potential regulatory functions, areas of signal enrichment must be considered relative to proximal genes and regulatory elements annotated throughout the target genome Regions of chromatin association by transcriptional regulators should be distinguished as individual binding sites in order to enhance downstream analyses, such as the identification of known and novel consensus motifs. |
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