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Mapping the kinase domain of Janus Kinase 3 |
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| Authors: | Adams Christopher Aldous David J Amendola Shelley Bamborough Paul Bright Colin Crowe Sarah Eastwood Paul Fenton Garry Foster Martyn Harrison Trevor K P King Sue Lai Justine Lawrence Christopher Letallec Jean-Philippe McCarthy Clive Moorcroft Neil Page Kenneth Rao Sudha Redford Jane Sadiq Shazia Smith Keith Souness John E Thurairatnam Sukanthini Vine Mark Wyman Barry |
| Affiliation: | Aventis Pharmaceuticals, 1041 Route 202-206, PO Box 6800, Bridgewater, NJ 08807, USA. |
| Abstract: | The utilization and impact of parallel synthesis on lead exploration around initial hit oxindole (1) are described. The emergent SAR, analogue design and functional impact will also be detailed. |
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