Transient activation of c-myc protooncogene expression in Leydig cells by human chorionic gonadotropin |
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Authors: | T Lin J Blaisdell K W Barbour E A Thompson |
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Institution: | Medical Service, WJB Dorn Veterans Hospital, Columbia, SC. |
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Abstract: | This study evaluated the effects of in vivo administration of human chorionic gonadotropin (hCG) on c-myc oncogene expression in Leydig cells. Sprague-Dawley rats (46-50 days old) were treated with hCG (10 units, i.p.), and purified Leydig cells were isolated 1-24 h later. HCG caused a transient elevation of c-myc mRNA in 4 h and returned to normal or lower than normal levels at 24 h. There was no change in c-fos or beta-actin mRNA levels. Our results suggest that the growth promoting effects of hCG on Leydig cells may be mediated by the transient expression of c-myc protooncogene. |
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