一种家蚕类浓核病毒的组织病理学特征

本文从家蚕病蚕中分离到一种家蚕类浓核病毒（BmDNV-Like）,对它的组织病理学研究表明:该病毒首先寄生家蚕中肠柱状细胞，继而引起其细胞核的膨大和破裂；组织原位杂交结果表明该病毒既能在家蚕中肠柱状细胞中增殖，也能在中肠的杯形细胞中增殖，甚至在感染后期能在家蚕幼虫的大部分组织细胞中感染和增殖。

Histopathological characteristics of a densovirus-like from silkworm, Bombyx mori

A small icosahedral nonenveloped DNA virus with the main biological and biophysical properties of densoviruses (DNVs) was isolated from silkworm Bombyx mori with abnormal larval mortality. Histopathological studies suggested that the virus first parasited on columnar cell of midgut, and then the nucleus of columnar cell became extremely inflated, or even broken. In situ hybridization results also demonstrated the virus was first reproduced in nucleus of columnar cells among midgut epithelial cells. It can also infect and reproduce in the goblet cells and most of the larval tissues at the last stage of infected silkworm.