Peptide binding predictions for HLA DR,DP and DQ molecules |
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Authors: | Peng Wang John Sidney Yohan Kim Alessandro Sette Ole Lund Morten Nielsen Bjoern Peters |
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Institution: | 1.La Jolla Institute for Allergy and Immunology,La Jolla,USA;2.Center for Biological Sequence Analysis, Department for Systems Biology,Technical University of Denmark,Lyngby,Denmark |
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Abstract: | Background MHC class II binding predictions are widely used to identify epitope candidates in infectious agents, allergens, cancer and
autoantigens. The vast majority of prediction algorithms for human MHC class II to date have targeted HLA molecules encoded
in the DR locus. This reflects a significant gap in knowledge as HLA DP and DQ molecules are presumably equally important,
and have only been studied less because they are more difficult to handle experimentally. |
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Keywords: | |
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