<Emphasis Type="Italic">In vivo</Emphasis> studies with a <Emphasis Type="Italic">Candida tropicalis</Emphasis> isolate exhibiting paradoxical growth <Emphasis Type="Italic">in vitro</Emphasis> in the presence of high concentration of caspofungin |
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Authors: | Sedigh Bayegan Laszlo Majoros Gabor Kardos Adam Kemény-Beke Cecilia Miszti Renato Kovacs Rudolf Gesztelyi |
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Institution: | 1.Department of Medical Microbiology, Medical and Health Science Center,University of Debrecen,Debrecen,Hungary;2.Department of Ophthalmology, Medical and Health Science Center,University of Debrecen,Debrecen,Hungary;3.Department of Pharmacology, Medical and Health Science Center,University of Debrecen,Debrecen,Hungary |
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Abstract: | We investigated the activity of caspofungin against a Candida tropicalis clinical isolate showing paradoxical growth in vitro. BALB/c mice immunosuppressed by cyclophosphamide were infected intraperitoneally using 107 CFU/mouse. Caspofungin was administered intraperitoneally once daily for 5 days or as a single dose using the following doses:
0.12, 0.25, 1, 2, 3, 5, and 15 mg/kg. The single dose of caspofungin was effective only at 5 and 15 mg/kg concentrations (100%
survival). Five-day caspofungin treatment led to 100% survival at doses of 1 mg/kg or higher. Caspofungin treatment significantly
decreased the number of viable yeasts in the peritoneal lavage samples as well as in the infected abscesses at doses 1, 3,
5, and 15 mg/kg caspofungin as compared to the untreated control (P<0.001 in all cases), and even to the group treated with 0.12 mg/kg caspofungin (P<0.05 in all cases). At 2 mg/kg caspofungin dose, sterilization of the internal organs was reproducibly incomplete, suggesting
that the role of paradoxical growth in the late clinical failure cannot be excluded. |
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Keywords: | |
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