Effect of growth temperature on virulence of strains of Listeria monocytogenes in the mouse: evidence for a dose dependence |
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Authors: | JC Stephens IS Roberts Dorothy Jones PW Andrew |
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Institution: | Department of Microbiology, University of Leicester, Leicester, UK |
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Abstract: | Growth of Listeria monocytogenes at 4°C significantly increased its virulence for mice by the intravenous route and the effect was dose-dependent. Virulence was apparent only at a dose of about or above 104 viable listerias. At slightly lower doses of about 103, no such effect was observed. Growth at 4°C did not increase the virulence of the strains for mice by oral-gastric challenge when given at doses of approximately 1010. |
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