| 上海地区汉族人5-HT2a受体基因T102C多态性的基因频率分布 |
| |
| 引用本文： | 罗星光,江三多,江开达,顾牛范,林嗣萃,钱伊萍LUO Xing-guang,JIANG San-duo,JIANG Kai-da,GU Niu-fan,LIN Si-cui,QIAN Yi-ping.上海地区汉族人5-HT2a受体基因T102C多态性的基因频率分布[J].遗传,1998,20(5):25-27. |
| |
| 作者姓名： | 罗星光 江三多 江开达 顾牛范 林嗣萃 钱伊萍LUO Xing-guang JIANG San-duo JIANG Kai-da GU Niu-fan LIN Si-cui QIAN Yi-ping |
| |
| 作者单位： | 1.上海医科大学精神医学教研室, 上海 200032
2.上海市精神卫生研究所遗传室，上海 200030
1.Department of Psychiatry,Shanghai Medical University,Shanghai 200032
2.Institute of Genetics,Shanghai Mental Health Center,Shanghai 200030 |
| |
| 摘 要： | 为了揭示中国汉族人5-HT2a受体基因T102C多态性基因频率的分布,我们随机抽取了226例汉族健康人作研究,用限制性片段长度多态性(RFLPs)技术测定研究对象的基因型和等位基因。结果发现汉族正常人5-HT2a受体基因T102C多态性基因型频率依次为:A1/A2=0.5044,A1/A1=0.2965,A2/A2 =0.1991,两种等位基因频率依次为:A1=0.5487,A2=0.4513,杂合度H=0.50 44、期望杂合度h=0.4953,多态信息量PIC=0.3726,表明T102C多态性具有合适信息,对疾病的关联研究,法医学鉴定有一定的价值。
Abstract:To investigate the distribution about genotype and allele frequencies of T102C polymorphism in the 5-HT2a receptor gene Chinese Han population,the genotypes and alleles of 226 healthy person were examined with Restriction Fragment Length Polymorphisms(RFLPs)technique.The genotype frequencies are as follows:A1/A2=0.5044,A1/A1=0.2965,A2/A2=0.1991,respectively,and the allele frequencies are as follows:A1=0.5487,A2=0.4513,respectively.The heterozygosity(H)is 0.5044,the expected heterozygosity(h)is 0.4953,and the Polymorphism Information Content(PIC)is 0.3726.Our findings suggest that the T102C polymorphism in 5-HT2a receptor gene may have suitable information to be used for association study or forensic identification.
|
| 关 键 词： | 中国汉族人 5-HT2a受体基因 T102C polymorphism 5-HT2a receptor gene T102C多态性 Key words 荧光原位杂交 小鼠 转基因 定位 BNLF-1 |
A Study of the Distribution about Genotype and Allele Frequencies of T102C Polymorphism in the 5-HT2a Receptor Gene in Chinese Han Population in Shanghai |
| |
| LUO Xingguang,JIANG Sanduo,JIANG Kaida,GU Niufan,LIN Sicui,QIAN Yiping.A Study of the Distribution about Genotype and Allele Frequencies of T102C Polymorphism in the 5-HT2a Receptor Gene in Chinese Han Population in Shanghai[J].Hereditas,1998,20(5):25-27. |
| |
| Authors: | LUO Xingguang JIANG Sanduo JIANG Kaida GU Niufan LIN Sicui QIAN Yiping |
| |
| Institution: | LUO Xingguang 1) JIANG Sanduo 2) JIANG Kaida 1) GU Niufan 1) LIN Sicui 2 QIAN Yiping 2) |
| |
| Abstract: | To investigate the distribution about genotype and allele frequencies of T102C polymorphism in the 5-HT2a receptor gene in Chinese Han population, the genotypes and alleles of 226 healthy person were examined with Restriction Fragment Length Polymorphisms(RFLPs) technique The genotype frequencies are as follows: A1/A2=0 5044,A1/A1=0 2965,A2/A2=0 1991,respectively, and the allele frequencies are as follows: A1=0 5487,A2=0 4513, respectively The heterozygosity(H) is 0 5044, the expected heterozygosity(h) is 0 4953, and the Polymorphism Information Content(PIC) is 0 3726 Our findings suggest that the T102C polymorphism in 5-HT2a receptor gene may have suitable information to be used for association study or forensic identification |
| |
| Keywords: | HT2a receptor gene T102Cpolymorphism Chinese Han population |
| 本文献已被 CNKI 维普 等数据库收录！ |
| 点击此处可从《遗传》浏览原始摘要信息 |
| 点击此处可从《遗传》下载免费的PDF全文 |
|
