The kinetic significance of cell size : II. Size distributions of resting and proliferating cells during interphase |
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Authors: | A Yen J Fried T Kitahara Annabel Strife B D Clarkson |
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Institution: | Department of Zoology, University of California, Davis, CA 95616, USA |
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Abstract: | This second part in a two part report describes the kinetic, cell size and nuclear size characteristics of S phase cells and cells with greatly protracted generation times (‘resting’ cells) in a cell line of human lymphoid cells. The median cell and nuclear sizes of S phase cells were greater than the corresponding median sizes observed in the whole population. Resting cells (operationally defined as unlabelled cells after 5 days of continuous labelling with 3H]TdR) have cell and nuclear size distributions overlapping with the cell and nuclear size distributions of the whole population. These resting cells are kinetically characterized by means of the observed labelling index vs time data during continuous labelling. The implication of these results are discussed. |
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Keywords: | Reprint requests should be sent to: A Yen Section 6210 Memorial Sloan-Kettering Cancer Center 1275 York Avenue New York NY 10021 USA |
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