Classification of conformation for sugar amino acid systems using chiroptical spectroscopy |
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Authors: | Edwards Alison A Fleet George W J Tranter George E |
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Affiliation: | Biological Chemistry, Division of Biomedical Sciences, Imperial College, London, United Kingdom. alison.edwards@imperial.ac.uk |
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Abstract: | A number of structurally related sugar amino acid systems have been examined by chiroptical methods to aid interpretation of their conformational preference. The use of circular dichroism, in addition to NMR and solution IR, has enabled classification of the conformations adopted by sugar amino acid systems as hydrogen-bonded regular, non-hydrogen-bonded regular, and non-hydrogen-bonded irregular. A set of tetrameric SAAs are examined and the effect of change in primary structure related to conformation. |
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Keywords: | circular dichroism sugar amino acids dipeptide isosteres peptidomimetics conformation hydrogen bonding |
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