Heterogeneity in head and neck cancer incidence among black populations from Africa,the Caribbean and the USA: Analysis of cancer registry data by the AC3 |
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| Affiliation: | 1. Guadeloupe Cancer Registry, University Hospital of Guadeloupe, Pointe-à-Pitre, Guadeloupe, France;2. The National Cancer Registry, Kenya Medical Research Institute, Nairobi, Kenya;3. University of Miami, Sylvester Comprehensive Cancer Center, FL, USA;4. Department of Epidemiology and Public Health and the Institute of Human Virology, The Marlene and Stewart Greenebaum Comprehensive Cancer Centre, University of Maryland School of Medicine, Baltimore, MD, USA;5. Center for Bioethics and Research, Ibadan, Nigeria;6. Nigerian National System of Cancer Registries, Federal Ministry of Health, Abuja, Nigeria;7. Cancer Centre of Trinidad and Tobago, St. James, Trinidad and Tobago;8. Barbados National Registry, The George Alleyne Chronic Disease Research Centre, Caribbean Institute for Health Research, University of the West Indies, Cave Hill, Barbados;9. City of Hope Cancer Center, Duarte, CA, USA;10. Kumasi Cancer Registry, Komfo Anokye Teaching Hospital, Kumasi, Ghana;11. Department of Anatomical Sciences, St Georges University, Grenada, West Indies;12. Calabar Cancer Registry, Department of Pathology, College of Medical Sciences, University of Calabar and Teaching Hospital, Calabar, Nigeria;13. Department of Community Health, Faculty of Clinical Sciences, College of Health Sciences, University of Uyo/University of Uyo Teaching Hospital, Uyo, Nigeria;14. Enugu Cancer Registry, University of Nigeria Teaching Hospital, Enugu, Nigeria;15. Dr. Elizabeth Quamina Cancer Registry, the National Cancer Registry of Trinidad and Tobago, Mount Hope, Trinidad and Tobago;p. Department of Lab Medicine, Kenyatta National Hospital, Nairobi, Kenya;q. Biological Resource Center Karubiotec™, BRIF n° KARUBIOTEC-GUA-00971, Pointe-à-Pitre, Guadeloupe;r. Jamaica Cancer Registry, Department of Pathology, University of the West Indies, Kingston, Jamaica;s. Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, PA, USA;t. National Hospital Abuja, Abuja, Nigeria;u. Department of Otorhinolaryngology/Head &Neck Surgery, Faculty of Clinical sciences, Usmanu Danfodiyo University/Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria;v. Population Based Cancer Registry, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria;w. Liguanea Family Dental Centre, Seymour Park, Kingston, Jamaica;x. Department of Epidemiology, Mailman School of Public Health, Columbia University Irving Medical Center, New York, USA;y. Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) – UMR_S 1085, Pointe-à-Pitre, Guadeloupe, France;z. Center for Big Data Research in Health, University of New South Wales, Sydney, Australia;11. Department of Anatomic Pathology, Ekiti State University and Teaching Hospital, Ado-Ekiti, Nigeria;12. Abuja Cancer Registry, Department of Haematology and Blood Transfusion, University of Abuja Teaching Hospital, Gawgwalada, Nigeria;13. Department of Pathology, Federal Medical Centre, Yola, Nigeria;14. Dental Department, Katutura State Hospital, Windhoek, Namibia;15. African Caribbean Cancer Consortium USA;1. Registre du Cancer de l’Isère, Grenoble, BP 217, 38043 Grenoble Cedex 09, France;2. Centre Hospitalier Universitaire Grenoble Alpes, Pôle Santé Publique, Service d''évaluation médicale, BP 217, 38043 Grenoble Cedex 09, France;3. Université Grenoble Alpes, Laboratoire Techniques de l''Ingénierie Médicale et de la Complexité - Informatique Mathématiques et Applications, Grenoble, France;1. Registre Général des cancers de la Martinique, UF 1441 Registre des cancers, Pôle de Cancérologie Hématologie Urologie Pathologie, CHU de Martinique, 97200 Fort-de-France, Martinique, France;2. Pôle de Gériatrie, CHU de Martinique, 97200 Fort-de-France, Martinique, France;3. Faculté de Médecine, EA 3797, Université de Reims Champagne-Ardenne, 51095 Reims, France;4. Unité d''aide Méthodologique, Pôle Recherche et Santé publique, CHU de Reims, 51000 Reims, France;5. Université des Antilles, EA929 groupe BIOSPHERES, Campus de Schœlcher, 97200 Fort-de-France, Martinique, France;6. Département de Médecine Interne et Gériatrie, CHU de Reims, 51000 Reims, France;1. Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO, USA;2. Data Analytics Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, MD, USA;3. Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA;4. Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA;1. University of Ioannina, Stavros Niarchou Avenue, Ioannina 45110, Greece;2. Gustave Roussy, Département de médecine oncologique, F-94805 Villejuif, France;3. Department of Hematology-Oncology, Faculty of Medicine, Saint Joseph University, Beirut 166830, Lebanon;4. Department of Medical Oncology, Antwerp University Hospital, Edegem, Belgium;5. Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium;6. King’s College London, Faculty of Life Sciences & Medicine, School of Cancer & Pharmaceutical Sciences, SE1 9RT London, UK;7. Medway NHS Foundation Trust, Windmill Road, Gillingham, Kent ME7 5NY, UK;8. AELIA Organization, 9th Km Thessaloniki-Thermi, Thessaloniki 57001, Greece;9. School of Community Health Sciences, University of Nevada, Reno, NV, USA;1. UF 1441 Registre Général des cancers de la Martinique, Pôle de Cancérologie Hématologie Urologie Pathologie, CHU de Martinique, 97200, Fort-de-France, Martinique;2. UF 3163, Unité de soutien méthodologique à la Recherche, Délégation de la Recherche et de l’innovation, CHU Martinique, 97200, Fort-de-France, Martinique;3. Pôle de Cancérologie Hématologie Urologie Pathologie, CHU de Martinique, 97200, Fort-de-France, Martinique;1. The Cancer Centre, Queen Elizabeth Hospital, Birmingham, University Hospitals Birmingham NHS Trust, UK;2. School of Cancer Sciences, University of Birmingham, Birmingham, UK;3. Cancer Research Unit, Clinical Trials Unit, University of Warwick, Coventry, UK |
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| Abstract: | BackgroundAfrica and the Caribbean are projected to have greater increases in Head and neck cancer (HNC) burden in comparison to North America and Europe. The knowledge needed to reinforce prevention in these populations is limited. We compared for the first time, incidence rates of HNC in black populations from African, the Caribbean and USA.MethodsAnnual age-standardized incidence rates (IR) and 95% confidence intervals (95%CI) per 100,000 were calculated for 2013–2015 using population-based cancer registry data for 14,911 HNC cases from the Caribbean (Barbados, Guadeloupe, Trinidad & Tobago, N = 443), Africa (Kenya, Nigeria, N = 772) and the United States (SEER, Florida, N = 13,696). We compared rates by sub-sites and sex among countries using data from registries with high quality and completeness.ResultsIn 2013–2015, compared to other countries, HNC incidence was highest among SEER states (IR: 18.2, 95%CI = 17.6–18.8) among men, and highest in Kenya (IR: 7.5, 95%CI = 6.3–8.7) among women. Nasopharyngeal cancer IR was higher in Kenya for men (IR: 3.1, 95%CI = 2.5–3.7) and women (IR: 1.5, 95%CI = 1.0–1.9). Female oral cavity cancer was also notably higher in Kenya (IR = 3.9, 95%CI = 3.0–4.9). Blacks from SEER states had higher incidence of laryngeal cancer (IR: 5.5, 95%CI = 5.2–5.8) compared to other countries and even Florida blacks (IR: 4.4, 95%CI = 3.9–5.0).ConclusionWe found heterogeneity in IRs for HNC among these diverse black populations; notably, Kenya which had distinctively higher incidence of nasopharyngeal and female oral cavity cancer. Targeted etiological investigations are warranted considering the low consumption of tobacco and alcohol among Kenyan women. Overall, our findings suggest that behavioral and environmental factors are more important determinants of HNC than race. |
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| Keywords: | Head and neck cancer Incidence Blacks Tobacco smoking Alcohol drinking HPV Caribbean Africa USA Population-based cancer registry |
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