Influenza A Viruses Expressing Intra- or Intergroup Chimeric Hemagglutinins |
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| Authors: | Chi-Jene Chen Megan E Ermler Gene S Tan Florian Krammer Peter Palese Rong Hai |
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| Institution: | aDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA;bDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA |
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| Abstract: | A panel of influenza A viruses expressing chimeric hemagglutinins (cHA) with intragroup or intergroup head/stalk combinations was generated. Viruses were characterized for growth kinetics and preservation of stalk epitopes. With a few notable exceptions, cHA viruses behaved similarly to wild-type viruses and maintained stalk epitopes, which indicated their potential as vaccine candidates to induce stalk-specific antibodies. |
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