IL-10 inhibits Fc epsilon RI expression in mouse mast cells |
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Authors: | Gillespie Sheila R DeMartino Randall R Zhu Jingfang Chong Hey Jin Ramirez Carlos Shelburne Christopher P Bouton L Andrew Bailey Daniel P Gharse Anita Mirmonsef Paria Odom Sandra Gomez Gregorio Rivera Juan Fischer-Stenger Krista Ryan John J |
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Institution: | Department of Biology, Virginia Commonwealth University, Richmond, VA 23284, USA. |
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Abstract: | FcepsilonRI expression and function is a central aspect of allergic disease. Using bone marrow-derived mouse mast cell populations, we have previously shown that the Th2 cytokine IL-4 inhibits FcepsilonRI expression and function. In the current study we show that the Th2 cytokine IL-10 has similar regulatory properties, and that it augments the inhibitory effects of IL-4. FcepsilonRI down-regulation was functionally significant, as it diminished inflammatory cytokine production and IgE-mediated FcepsilonRI up-regulation. IL-10 and IL-4 reduced FcepsilonRI beta protein expression without altering the alpha or gamma subunits. The ability of IL-4 and IL-10 to alter FcepsilonRI expression by targeting the beta-chain, a critical receptor subunit known to modulate receptor expression and signaling, suggests the presence of a Th2 cytokine-mediated homeostatic network that could serve to both initiate and limit mast cell effector function. |
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