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Alkaloids from Heimia salicifolia |
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| Authors: | Rumalla Chidananda Swamy Jadhav Atul N Smillie Troy Fronczek Frank R Khan Ikhlas A |
| Affiliation: | aNational Center for Natural Products Research, University of Mississippi, MS 38677, USA bDepartment of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA cDepartment of Pharmacognosy, School of Pharmacy, University of Mississippi, MS 38677, USA |
| Abstract: | Two alkaloids, 9β,2′-dihydroxy-4′′,5′′-dimethoxy-lythran-12-one or 9β-hydroxyvertine (1) and (2S,4S,10R)-4-(3-hydroxy-4-methoxyphenyl)-quinolizidin-2-acetate (2), as well as seven known alkaloids, lythrine (3), dehydrodecodine (4), lythridine (5), vertine (6), heimidine (7), lyfoline (8) and epi-lyfoline (9), were isolated from Heimia salicifolia. The structures of these compounds were elucidated by extensive spectroscopic techniques. Furthermore, the structures of 2, 3, and 6 were confirmed by X-ray crystallography, including absolute configuration determination of 2 and 6. Compounds 6 and 9 showed moderate antimalarial activity. |
| Keywords: | Heimia salicifolia Lythraceae Alkaloids X-ray crystallography |
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