Hepatocyte differentiation during early fetal development in the rat |
| |
Authors: | Dr. Annarosa Ciofi Luzzatto |
| |
Affiliation: | (1) Istituto di Istologia ed Embriologia, Facoltà di Scienze, M.F.N. Università di Roma, Rome, Italy;(2) Istituto di Istologia ed Embriologia, Facoltà di Scienze, M.F.N., Università di Roma, Città Universitaria, Rome, Italy |
| |
Abstract: | Summary Rat hepatocyte differentiation between day 12 and 19 of fetal life was studied by electron microscopy. The cytoplasmic structures involved in synthetic and secretory function, i.e., rough endoplasmic reticulum and Golgi apparatus, appear to be the first to differentiate, and their development is probably related to the secretion of different kinds of plasma proteins. The cytoplasmic organelles involved in other hepatic functions develop later: lysosomes from day 15, peroxysomes, glycogen rosettes and smooth endoplasmic reticulum still later. However, the morphological differentiation of bile canaliculi begins from day 12.This work was supported in part by a grant from C.N.R. n. 78.02265.04 |
| |
Keywords: | Rat fetus Hepatocyte differentiation Ultrastructure Electron microscopy |
本文献已被 SpringerLink 等数据库收录! |
|