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Iron uptake by Chinese hamster fibroblasts from human transferrin
Authors:S Smit  MIE Huijskes-Heins  B Leijnse
Institution:Department of Chemical Pathology, Medical Faculty, Erasmus University, Rotterdam, The Netherlands
Abstract:The manner of uptake or iron by Chinese hamster fibroblasts, type DON, from human transferrin was investigated by means of replacement studies, in which the cells that were incubated with 125I-labelled human transferrin were chased with non-radioactive transferrin for only a few minutes. The results did not support the reversible endocytosis hypothesis for the uptake of iron from transferrin. The uptake of iron measured as 59Fe during several cell divisions was found to be a function of time and cell number. It was found that the total uptake of iron in the harvests was directly proportional to the incubation, and that the uptake per 106 cells levelled off in the course of time.
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