Eimeria tenella,E. necatrix,E. acervulina,and E. maxima: Anticoccidial activity of 1,6-dihydro-6-oxo-2-pyrazinecarboxylic acid 4-oxide |
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Authors: | Toshimi Matsuno Nobuo Kobayashi Fumio Hariguchi Toshiyuki Yamazaki Kin-ichi Imai Hiroshi Onaga |
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Institution: | Animal Health Products Division, Takeda Chemical Industries, Ltd., Yodogawa-ku, Osaka 532, Japan;Nippon Institute for Biological Science, Shin-machi, Ome, Tokyo 198, Japan |
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Abstract: | The anticoccidial activity of an orotic acid analog, 1,6-dihydro-6-oxo-2-pyrazinecarboxylic acid 4-oxide (carboxyemimycin), was tested in battery experiments, utilizing 9-day-old Single-Comb White Leghorn cockerels. Carboxyemimycin, at 125 ppm and more in feed, exhibited marked anticoccidial activities against Eimeria tenella, E. necatrix, E. acervulina, and E. maxima. High doses of carboxyemimycin—up to 1000 ppm—did not cause any reduction in weight gains. The battery and in vitro studies with delayed and restricted medications revealed that carboxyemimycin affected the development of E. tenella in first and second generation schizogony and in gametogony. |
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Keywords: | Protozoa parasitic Chicken Treatment Anticoccidial activity Orotic acid analog 1 6-Dihydro-6-oxo-2-pyrazinecarboxylic acid 4-oxide |
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