Mutation of the gene for the second-largest subunit of RNA polymerase I prolongs the period length of the circadian conidiation rhythm in Neurospora crassa |
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Authors: | K. Onai S. Katagiri M. Akiyama H. Nakashima |
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Affiliation: | (1) Department of Biology, Faculty of Science, Okayama University, Okayama 700, Japan Fax: +81-086-251-7858; e-mail: yfdh0614@cc.okayama-u.ac.jp, JP |
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Abstract: | The period length of the circadian conidiation rhythm was examined in a mutant strain of Neurospora crassa, un-18, that is temperature sensitive for mycelial growth. The un-18 mutant showed a temperature-sensitive phenotype with respect to both mycelial growth and the period length of the conidiation rhythm. Below 22° C, the un-18 mutation did not affect the period length, but at temperatures between 22° C and 32° C, the period length of the un-18 mutant was ∼2 h longer than that of the wild-type strain. The un-18 + gene was cloned and was found to encode the second-largest subunit of RNA polymerase I, which is involved in the synthesis of rRNA. These results indicate that a defect in ribosome synthesis, which must result in a lower rate of protein synthesis, lengthens the period of the circadian conidiation rhythm in Neurospora. Received: 17 October 1997 / Accepted: 26 April 1998 |
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Keywords: | Circadian rhythm Neurospora crassa Temperature-sensitivity un-18 Second-largest subunit of RNA polymerase I |
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