Inhibition of melanization by a Nasonia defensin-like peptide: Implications for host immune suppression |
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| Authors: | Caihuan Tian Gongyin Ye |
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| Institution: | a Group of Animal Innate Immunity, State Key Laboratory of Integrated Management of Pest Insects & Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, PR China
b State Key Laboratory of Rice Biology, Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310029, PR China |
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| Abstract: | The parasitic wasp Nasonia vitripennis suppresses host immune mechanisms that include melanization reactions. Melanization is an important immune response of hosts induced by wasp infection and thus its inhibition represents a successful strategy for parasitism. However, the molecular basis associated with such inhibition is largely unknown in N. vitripennis. Here, we report recombinant expression, structural and functional characterization of a Nasonia-derived defensin-like peptide (called nasonin-3) whose recombinant product exerts inhibitory effect on host melanization. The possible role of nasonin-3 in immune suppression is also discussed. |
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| Keywords: | Innate immunity Nasonin-3 Parasitoid Recombinant expression Cysteine-stabilized α-helical and β-sheet motif |
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