Diverse bacterial genomes encode an operon of two genes, one of which is an unusual class-I release factor that potentially recognizes atypical mRNA signals other than normal stop codons |
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| Authors: | Pavel V Baranov Bente Vestergaard Thomas Hamelryck Raymond F Gesteland Jens Nyborg John F Atkins |
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| Institution: | (1) Bioscience Institute, University College Cork, Cork, Ireland;(2) Department of Human Genetics, University of Utah, 15N 2030E, Salt Lake City, 84112-5330, UT, USA;(3) Department of Molecular Biology, University of Aarhus, Gustav Wieds Vej 10C, DK-8000 Aarhus C, Denmark;(4) Department of Medicinal Chemistry, Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK-2100 Copenhagen, Denmark;(5) Bioinformatics center, Institute of Molecular Biology and Physiology, University of Copenhagen, Universitetsparken 15 Building 10, 2100 Copenhagen, Denmark |
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| Abstract: | Background While all codons that specify amino acids are universally recognized by tRNA molecules, codons signaling termination of translation
are recognized by proteins known as class-I release factors (RF). In most eukaryotes and archaea a single RF accomplishes
termination at all three stop codons. In most bacteria, there are two RFs with overlapping specificity, RF1 recognizes UA(A/G)
and RF2 recognizes U(A/G)A. |
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