Two-nucleotide codon change in a hemoglobin polymorphism of the Celebes black ape (Macaca nigra) |
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Authors: | Mitsuo Murata Peter E Thompson |
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Institution: | (1) Department of Zoology, The University of Georgia, Athens, Georgia |
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Abstract: | A hemoglobin polymorphism involving variant -chains was demonstrated in the Celebes black ape, Macaca nigra. Fingerprinting and amino acid analysis of the tryptic peptides from the two chain types have shown that they differ by a single amino acid substitution, between lysine and aspartic acid, which requires a two-nucleotide change in the corresponding codon. Another substitution in the same codon is found as a species difference between the black ape -chain and that of other macaques. |
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Keywords: | hemoglobin polymorphism macaque codon mutation |
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