Fluorene‐based boronic acids as fluorescent chemosensor for monosaccharides at physiological pH |
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| Authors: | Rahman Hosseinzadeh Maryam Mohadjerani Mona Pooryousef |
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| Affiliation: | 1. Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran;2. Department of Molecular and Cell Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran |
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| Abstract: | Two fluorene‐based boronic acids, 9,9‐dimethyl‐9H‐fluoren‐2‐yl‐2‐boronic acid (1) and 9,9‐dimethyl‐9H‐fluoren‐2,7‐diyl‐2,7‐diboronic acid (2), were synthesized and their sensing abilities for detection of D ‐monosaccharides were investigated by fluorescence at physiological pH. It was found that both boronic acids 1 and 2 have high selectivity and sensitivity for D ‐fructose with stability constant of 47.2 and 412.9, respectively. The sensor 2 showed a linear response toward D ‐fructose in the concentration range from 5 × 10–5 to 10–1 mol L–1 with the detection limit of 2 × 10–5 mol L–1. Copyright © 2014 John Wiley & Sons, Ltd. |
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| Keywords: | fluorescence boronic acid fluorene saccharide chemosensor |
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