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Impact of Apo E gene polymorphism on HCV therapy related outcome in a cohort of HCV Egyptian patients |
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| Authors: | Howayda E. Gomaa Mohamed Mahmoud Nevine E. Saad Amal Saad-Hussein Somaia Ismail Eman H. Thabet Hebatallah Farouk Dina Kandil Ahmed Heiba Wael Hafez |
| Affiliation: | 1. Clinical Pathology Department, National Research Centre, El-Behoos Street, Giza, Egypt;2. Internal Medicine Department, National Research Centre, Egypt;3. Environmental and Occupational Medicine Department, National Research Centre, Egypt;4. Medical Molecular Genetics Department, National Research Centre, Egypt |
| Abstract: | The functional apolipoprotein E (Apo E) gene polymorphism could be used as a determinant of outcome of HCV infection. This study aimed to demonstrate the impact of Apo E genotype on the response to HCV combined therapy. Material and methods: The study has been implemented on 125 individuals with persistent HCV infection and 120 cases with sustained virologic response (SVR). All participants were genotyped for ApoE gene polymorphism by a real-time quantitative PCR (qPCR). Results: Statistically significant differences were demonstrated regarding the Apo E genotypes between the two groups (P-value? |
| Keywords: | HCV genotype 4 Apolipoprotein E genotyping Response to HCV combined therapy |
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