Combined treatment of advanced malignant melanoma with coumarin and cimetidine |
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Authors: | Lise Pedersen Carsten Rose Eyvind Langvad |
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Institution: | (1) Dept. of Oncology ONA, The Finsen Institute, 49, Strandboulevarden, DK-2100 Copenhagen 0, Denmark |
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Abstract: | Summary Immunostimulant therapy with coumarin and cimetidine was evaluated in 17 patients with advanced malignant melanoma. Induction therapy with coumarin 100 mg daily was given for 8 weeks, whereupon cimetidine 1000 mg daily was added. No patients had been previously treated with cytotoxic drugs, and all patients had a good performance status. In 16 patients progressive disease was observed, and only 1 patient experienced no change in condition, lasting 30 weeks. We conclude that treatment with this schedule of coumarin and cimetidine is without effect in advanced malignant melanoma. |
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