Effect of bioprocess conditions on growth and alkaline protease production by halotolerant <Emphasis Type="Italic">Bacillus licheniformis</Emphasis> BA17 |
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Authors: | I E Nikerel Ö Ateş E T Öner |
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Institution: | (1) Department of Biotechnology, TU Delft, 2628 BC Delft, The Netherlands;(2) Department of Chemical Engineering, Marmara University, Goztepe, 34722 Istanbul, Turkey |
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Abstract: | The effect of bioprocess conditions (pH and temperature) on the growth and alkaline protease production of halotolerant Bacillus licheniformis BA17 bioreactor cultures have been systematically analyzed using response surface methodology in order to assess the importance
of these generally disregarded parameters. Two models were proposed differing by the choice of response variable. Under optimized
bioprocess conditions, whole alkaline protease activity was about 3 fold higher than the activities obtained in the preliminary
studies. Results of this study not only highlight the importance of pH and temperature for further engineering purposes but
also serve as basis for understanding the true mechanism lying under the relation between these process parameters and growth
and whole alkaline protease production.
Published in Russian Prikladnaya Biokhimiya i Mikrobiologiya, 2008, Vol. 44, No. 5, pp. 539–544.
The text was submitted by the autors in English. |
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