The effect of iron on mammalian cortical neurons in culture |
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| Authors: | Kenneth F. Swaiman Valynda L. Machen |
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| Affiliation: | (1) Division of Pediatric Neurology, University of Minnesota Medical School, 420 S. E.Delaware Street, Box 380 Mayo Building, 55455 Minneapolis, Minnesota |
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| Abstract: | We added iron in the ferric form to predominantly neuronal, cortical cell cultures, and determined clonazepam-displaceable [3H]diazepam binding, choline acetyltransferase activity, high-affinity [3H]GABA uptake, and glutamic acid decarboxylase activity. Chronic exposure (14 days) to low concentrations (0.01, 0.04, and 0.1  g/ml) of added ferric iron resulted in a significant decrease in each of the measures studied. |
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