Chimeric T helper-B cell peptides induce protective response against Japanese encephalitis virus in mice |
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| Authors: | Dewasthaly Shailesh Shyam Bhonde Gauri Sanjay Shankarraman Vasudha Biswas S Moanaro Ayachit Vijay Madhukar Gore Milind Madhukar |
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| Affiliation: | National Institute of Virology, Pune 411 001, India. |
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| Abstract: | Virus neutralizing MAb binding and T helper cell stimulating peptide epitopes from structural and non-structural proteins of Japanese encephalitis virus were delineated. It was observed that priming by T helper peptides potentiated neutralizing antibody response against JE virus. Immunization with chimeric T helper - B cell peptides could thus protect mice from lethal challenge with JE virus. |
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