Mitochondria as sensors and regulators of calcium signalling |
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Authors: | Rosario Rizzuto Diego De Stefani Anna Raffaello Cristina Mammucari |
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Institution: | Department of Biomedical Sciences, University of Padua and CNR Neuroscience Institute, Via G. Colombo 3, 35131 Padua, Italy. |
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Abstract: | During the past two decades calcium (Ca(2+)) accumulation in energized mitochondria has emerged as a biological process of utmost physiological relevance. Mitochondrial Ca(2+) uptake was shown to control intracellular Ca(2+) signalling, cell metabolism, cell survival and other cell-type specific functions by buffering cytosolic Ca(2+) levels and regulating mitochondrial effectors. Recently, the identity of mitochondrial Ca(2+) transporters has been revealed, opening new perspectives for investigation and molecular intervention. |
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