Influence of selenomethionine and vitamin E on the antioxidative system in animals with experimentally induced hypercholesterolemia |
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Authors: | Ewa Birkner Sławomir Kasperczyk Jolanta Zalejska-Fiolka Aleksandra Kasperczyk Beata Birkner |
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Institution: | (1) Department of Biochemistry, Silesian Medical University in Katowice, 41-808 Zabrze, Poland |
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Abstract: | The aim of this study was to investigate the effect of combined therapy of vitamin E and selenomethionine to pro/ antioxidant
status in experimental hypercholesterolemia. Thirty male rabbits were included in the study and randomized into five groups
consisting of the control group (standard diet) and four experimental groups staying on a diet rich in cholesterol (0.5 g/100
g diet): cholesterol group and groups supplemented cholesterol with selenomethionine (12.5 μg/kg body mass/24 h) or vitamin
E (10 mg of Dl-α-tocopherol/kg body mass/24 h) or combination of the above antioxidants for 3 mo. The activity of superoxide dismutase (SOD),
glutathione peroxidase (GPX), and catalase (CAT) as well as the concentration of malondialdehyde (MDA) was estimated in the
blood during every month of experiment. Increased activity of SOD and GPX with a decreased concentration of MDA in comparison
to the cholesterol diet was found mainly in the combination of study antioxidants. The supplementation of the cholesterol
diet with combined doses of vitamin E and selenomethionine appears to prevent the lesions induced by experimental hypercholesterolemia
much more efficiently than single doses of the above. |
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Keywords: | Hypercholesterolemia selenomethionine vitamin E rabbits antioxidative enzymes |
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