Characterization of a frequent polymorphism in the coding sequence of the Tp53 gene in colonic cancer patients and a control population |
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| Authors: | Sylviane Olschwang Pierre Laurent-Puig Anne Vassal Rémy-J. Salmon Gilles Thomas |
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| Affiliation: | (1) Laboratoire de Génétique Moléculaire des Tumeurs, Institut Curie, 26, Rue d'Ulm, F-75231 Paris Cedex 05, France |
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| Abstract: | Summary We describe a simple method for characterizing a frequent polymorphism (that subsitutes an arginine for a proline) in the coding sequence of the Tp53 gene in patients with colonic cancer and in a control population. We could find no evidence that this polymorphism is associated with a marked predisposition to colorectal cancer. |
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