Selection dramatically reduces effective population size in HIV-1 infection |
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Authors: | Yi Liu John E Mittler |
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Affiliation: | (1) Department of Microbiology, University of Washington School of Medicine, 98195 Seattle, Washington, USA |
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Abstract: | Background In HIV-1 evolution, a 100–100,000 fold discrepancy between census size and effective population size (N e ) has been noted. Although it is well known that selection can reduce N e , high in vivo mutation and recombination rates complicate attempts to quantify the effects of selection on HIV-1 effective size. |
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