| DNA修复酶MYH在食管鳞癌的表达和临床意义 |
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| 引用本文： | 张翔,成静,钱晓彬,吴莺,洪捷,姜坤,宋宏岩,印玉玮,高大庆.DNA修复酶MYH在食管鳞癌的表达和临床意义[J].现代生物医学进展,2010,10(6). |
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| 作者姓名： | 张翔 成静 钱晓彬 吴莺 洪捷 姜坤 宋宏岩 印玉玮 高大庆 |
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| 作者单位： | 1. 东南大学医学院,江苏,南京,210009
2. 江苏大学基础医学和医学技术学院,江苏,镇江,212017 |
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| 基金项目： | 江苏省自然科学基金(BK2007108) |
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| 摘 要： | 目的:探讨食管鳞癌组织MYH的表达与8-oxoG氧化损伤和临床病理特征之间的关系。方法:用免疫组化染色和Western blot实验,比较食管鳞癌组织和癌旁组织MYH表达的高低;用免疫组化染色比较食管鳞癌组织和癌旁组织8-oxoG氧化损伤程度的高低。统计分析食管鳞癌组织MYH表达的高低与患者临床和病理特征的关系,采用x2检验。结果:食管鳞癌组织MYH蛋白表达低于其癌旁组织,食管鳞癌组织8-oxoG氧化损伤程度高于其癌旁组织。食管鳞癌组织MYH蛋白低表达,与该组织8-oxoG氧化损伤程度、浸润深度、静脉侵犯、TNM分期、淋巴结转移有关,与年龄、性别、病理分化程度无关。结论:食管鳞癌组织MYH蛋白低表达,可能与食管鳞癌的发展有关,后常规对患者食管癌标本做MYH表达的检测,可指导食管鳞癌术后化学治疗方案的制定。
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| 关 键 词： | 食管鳞癌 MYH 8-oxoG |
Expression of DNA Repair Enzyme in Esophagus Squamous Cell Carcinoma and Its Clinical Significance |
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| ZHANG Xiang,CHENG Jing,QIAN Xiao-bin,WU Ying,HONG Jie,JIANG Kun,SONG Hong-yan,YIN Yu-wei,GAO Da-qing.Expression of DNA Repair Enzyme in Esophagus Squamous Cell Carcinoma and Its Clinical Significance[J].Progress in Modern Biomedicine,2010,10(6). |
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| Authors: | ZHANG Xiang CHENG Jing QIAN Xiao-bin WU Ying HONG Jie JIANG Kun SONG Hong-yan YIN Yu-wei GAO Da-qing |
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| Institution: | ZHANG Xiang1,CHENG Jing2,QIAN Xiao-bin2,WU Ying2,HONG Jie1,JIANG Kun1,SONG Hong-yan1,YIN Yu-wei1,GAO Da-qing1 (1 Southeast University,Nanning 210009,China,2 Jiangsu University,Zhenjiang 212017,China) |
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| Abstract: | Objective: To investigate the relationship between the expression of MYH in esophageal squamous cell carcinoma (ESCC) and its 8-oxoG oxidative damage,its clinical and pathologic characteristic.Methods: Immunohistochemical method and Western blot method were used to compare the expression of MYH protein between tissues of ESCC and tissues by the side of ESCC.Immunohistochemical method was used to detect the degree of 8-oxoG oxidative damage between them.Results: Decreased MYH expression was found in tissues ... |
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| Keywords: | Esophageal squamous cell carcinoma MYH 8-oxoG |
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