Novel halogenated sulfonamides inhibit the growth of multidrug resistant MCF-7/ADR cancer cells. |
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Authors: | J C Medina D Roche B Shan R M Learned W P Frankmoelle D L Clark T Rosen J C Jaen |
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Institution: | Tularik Inc., South San Francisco, CA 94080, USA. |
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Abstract: | In this report, we describe the synthesis of halogenated benzenesulfonamide compounds and their ability to inhibit the growth of HeLa, MCF-7 and MCF-7/ADR tumor cells in vitro. The multidrug resistance (MDR) phenotype of certain cells does not affect their sensitivity to these compounds. These agents belong to a family of compounds previously shown to bind irreversibly to cysteine-239 of beta-tubulin. Consistent with this mechanism of action, the cytotoxicities of these compounds appear to correlate with their ability to undergo nucleophilic aromatic substitution. |
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